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KMID : 0386520120210010053
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Research Institute of Korean Medicone
2012 Volume.21 No. 1 p.53 ~ p.63
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A Study on the Immune Modulation of Chunghwatang(CHT) in Atopic Dermatitis Animal Models
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Yoo Heon-Sook
Gim Seon-Bin
Song Hyang-Hee
Ji Joong-Gu
Bak Ji-Won
Kim Dong-Hee
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Abstract
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Objectives : The aim of this study was to investigate the effect of Chunghwatang (CHT) for atopic dermatitis.
Methods : CHT, a verified anti-oxidant and anti-inflammatory effect, was treated in atopic dermatitis animal model to investigate cytokine levels and immunoglobulin production.
Results : Clinical skin index was 47.1%, suggesting significant efficacy of CHT in atopic dermatitis treatment. Serum IL-4, IL-6, IL-13, TNF- and histamine productions were significantly decreased to 52.3%, 61.8%, 68.0%, 37.4%, and 46.6%, respectively. The production of IL-5 was decreased to 33.3%. The increase of Immunoglobulin IgG1 production along with IgE through the interaction of IgE and IL-4 induced by IL-4 and IL-13 were measured as 20.7% and 23.4%, respectively.
Conclusions : The results above, along with the in vitro test results, strongly supports the CHT samples as effective immunomodulator in AD treatments, suggesting its use in clinical practice and basic information for EBM.
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KEYWORD
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CHT(Chunghwatang), atopic dermatitis, cytokine, immunoglobulin
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